A-205804|cas 251992-66-2| DC Chem|Supplier|Price|Buy  

A-205804|cas 251992-66-2| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: A-205804|cas 251992-66-2,Purity: >98% ,Cat No. DC7044, In stock.

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A-205804|cas 251992-66-2 ,Synonym:  ,Chemical name: Thieno[2,3-c]pyridine-2-carboxamide,4-[(4-methylphenyl)thio]- ,Molecular Formula: C15H12N2OS2 ,MW:300.4

A-205804, cas 251992-66-2,Purity: >98%, Best Price and quality from DC Chemicals. A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.

A-205804 selectively inhibits the surface expression of the cell adhesion molecules ICAM-1 and E-selectin in human endothelial cells. A-205804 inhibites the IL-1β-induced expression of E-selectin (IC50 = 20 nM) and ICAM-1 (IC50 = 10 nM) with essentially the same level of potency as that for TNFα-induced expression. For reasons which are unclear, the ability of A-205804 to inhibit PMA-induced E-selectin expression is significantly reduced (IC50 > 1000 nM), but A-205804 is a potent inhibitor of ICAM-1 expression (IC50 = 40 nM) using this protein-kinase C-activating agent. [2]