GSK126|cas 1346574-57-9| DC Chem|Supplier|Price|Buy  

GSK126|cas 1346574-57-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: GSK126|cas 1346574-57-9,Purity: >98% ,Cat No. DC7042, In stock.

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GSK126|cas 1346574-57-9 ,Synonym: EZH2 inhibitor; GSK-126; GSK 126  ,Chemical name: (S)-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide ,Molecular Formula: C??H??N?O? ,MW:526.67

GSK126, cas 1346574-57-9,Purity: >98%, Best Price and quality from DC Chemicals. GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase with Ki value of 0.5 nM.

A potent, highly selective, S-adenosyl-methionine(SAM)-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. GSK126 is highly selective against other methyltransferases and multiple other protein classes, even 150-fold more selective for the closest EZH1 (Kiapp = 89 nM) and more than 1,000-fold selective for 20 other human methyltransferases, including both SET-domain-containing and non-SET domain-containing methyltransferases. It decreases global H3K27me3 levels and reactivates silenced polycomb repressive complex 2 (PRC2) target genes.