co-1686|cas 1374640-70-6| DC Chem|Supplier|Price|Buy  

co-1686|cas 1374640-70-6| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: co-1686|cas 1374640-70-6,Purity: >98% ,Cat No. DC7106, In stock.

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co-1686|cas 1374640-70-6 ,Synonym: AVL-301; CNX-419  ,Chemical name: 2-?Propenamide,N-?[3-?[[2-?[[4-?(4-?acetyl-?1-?piperazinyl)?-?2-?methoxyphenyl]?amino]?-?5-(trifluoromethyl)?-?4-?pyrimidinyl]?amino]?phenyl]?- ,Molecular Formula: C27H28F3N7O3 ,MW:555.55

co-1686, cas 1374640-70-6,Purity: >98%, Best Price and quality from DC Chemicals. CO-1686 is a novel, irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M(IC50=21 nM). 

CO-1686 inhibits p-EGFR with IC50 ranging from 62 to 187 nM in the mutant EGFR–expressing cells, while inhibits EGFR phosphorylation with IC50 of > 2,000 nM in the three WT EGFR–expressing cells. CO-1686 selectively inhibits growth of NSCLC cells expressing mutant EGFR with GI50 ranging from 7 to 32 nM, and induces apoptosis. CO-1686–resistant NSCLC cell lines exhibits signs of epithelial-mesenchymal transition and increased sensitivity to AKT inhibitors. [1] CO-1686 causes dose-dependent and significant tumor growth inhibition in all EGFR-mutant models as well as human EGFRL858R- and EGFRL858R/T790M-expressing transgenic mice. [1]