CNX-2006|cas 1375465-09-0| DC Chem|Supplier|Price|Buy  

CNX-2006|cas 1375465-09-0| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: CNX-2006|cas 1375465-09-0,Purity: >98% ,Cat No. DC7105, In stock.

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CNX-2006|cas 1375465-09-0 ,Synonym: CNX2006; CNX 2006  ,Chemical name: 2-Propenamide,N-[3-[[2-[[4-[[1-(2-fluoroethyl)-3-azetidinyl]amino]-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]- ,Molecular Formula: C26H27F4N7O2 ,MW:545.53

CNX-2006, cas 1375465-09-0,Purity: >98%, Best Price and quality from DC Chemicals. CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.

CNX-2006 is a novel irreversible EGFR tyrosine kinase inhibitor, specifically inhibits activating mutations of EGFR as well as the T790M mutation while having very weak inhibition at wild-type EGFR. In in vitro modeling of acquired resistance, continuous CNX-2006 treatment on drug-sensitive EGFR mutant cells leads to resistance more slowly than erlotinib. Dose escalation with CNX-2006 leads to differential effects in different lines, but does not select for T790M-mediated resistance. [1]CNX-2006 resistent cells shows increased expression of EMT markers and MMP9.[2]