CNX-1351|cas 1276105-89-5| DC Chem|Supplier|Price|Buy  

CNX-1351|cas 1276105-89-5| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: CNX-1351|cas 1276105-89-5,Purity: >98% ,Cat No. DC7104, In stock.

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CNX-1351|cas 1276105-89-5 ,Synonym: CNX-1351; CNX 1351; CNX1351. ,Chemical name: 1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione ,Molecular Formula: C30H35N7O3S ,MW:573.71

CNX-1351, cas 1276105-89-5,Purity: >98%, Best Price and quality from DC Chemicals. CNX-1351 is a selective covalent Inhibitor of PI3Kα. CNX-1351 was tested against all four of the class I PI3K enzymes α, β, γ, and δ. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20?400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα.  CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α.

CNX-1351 is a selective covalent Inhibitor of PI3Kα. CNX-1351 was tested against all four of the class I PI3K enzymes α, β, γ, and δ. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20?400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα.  CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α.