WHI-P97|cas 211555-05-4|DC Chemicals

WHI-P97|cas 211555-05-4|DC Chemicals

WHI-P97 is a rationally designed potent inhibitor of JAK-3.

IC50 value:

Target: JAK3

Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations.

Product Name: WHI-P97|Cat No: DC9494|Cas: 211555-05-4|Molecule Formular: C16H13Br2N3O3|Molecule Weight: 455.1007|Other names: WHI-P97

WHI-P97 is a rationally designed potent inhibitor of JAK-3.
Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal. WHI-P97 was very well tolerated in mice, with no signs of toxicity at dose levels ranging from 5 microg/kg to 50 mg/kg, and LD(10) was not reached at a 50 mg/kg dose level when administered as a single i. p. or i.v. bolus dose.

For research only, not for human use!