ARRY-520 (R enantiomer)|cas 885060-08-2|DC Chemicals

ARRY-520 (R enantiomer)|cas 885060-08-2|DC Chemicals

ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.

IC50 Value:

Target: Ksp

ARRY-520 had low nanomolar antiproliferative activity in tumor cell lines.

Product Name: ARRY-520 (R enantiomer)|Cat No: DC9495|Cas: 885060-08-2|Molecule Formular: C20H22F2N4O2S|Molecule Weight: 420.4761|Other names: ARRY-520 (R enantiomer)

ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
ARRY-520 had low nanomolar antiproliferative activity in tumor cell lines. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent does not cause the peripheral neuropathy that is often associated with tubulin-targeting agents. KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.

For research only, not for human use!