Methylnaltrexone (Bromide)|cas 73232-52-7|DC Chemicals

Methylnaltrexone (Bromide)|cas 73232-52-7|DC Chemicals.

Methylnaltrexone Bromide is a pheriphally-acting μ-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation.

IC50 Value:

Target: Opioid Receptor

Methylnaltrexone is one of the newer agents of peripherally-acting μ-opioid antagonists that act to reverse some of the side effects of opioid drugs such as constipation without affecting analgesia or precipitating withdrawals.

Product Name: Methylnaltrexone (Bromide)|Cat No: DC9527|Cas: 73232-52-7|Molecule Formular: C21H26BrNO4|Molecule Weight: 436.3394|Other names: Methylnaltrexone (Bromide)

Methylnaltrexone Bromide is a pheriphally-acting μ-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation.
Methylnaltrexone is one of the newer agents of peripherally-acting μ-opioid antagonists that act to reverse some of the side effects of opioid drugs such as constipation without affecting analgesia or precipitating withdrawals. Because Methylnaltrexone contains a permanently charged tetravalent nitrogen atom, it cannot cross the blood-brain barrier, and so has antagonist effects throughout the body, counteracting effects such as itching and constipation, but without affecting opioid effects in the brain such as analgesia. However, since a significant fraction (up to 60 %) of opioid analgesia can be mediated by opioid receptors on peripheral sensory neurons, particularly in inflammatory conditions such as arthritis, traumatic or surgical pain, Methylnaltrexone may increase pain under such circumstances.

For research only, not for human use!