Meptazinol (hydrochloride)|cas 59263-76-2|DC Chemicals

Meptazinol (hydrochloride)|cas 59263-76-2|DC Chemicals

Meptazinol Hcl(WY-22811 Hcl) is a unique centrally active opioid analgesic.

IC50 Value: < 1 nM [1]

Target: Opioid Receptor

in vitro: Meptazinol inhibits a portion of 3H-labeled opiate and opioid peptide binding quite potently, with IC50 value under 1 nM [1]..

Product Name: Meptazinol (hydrochloride)|Cat No: DC9526|Cas: 59263-76-2|Molecule Formular: C15H24ClNO|Molecule Weight: 269.8102|Other names: Meptazinol (hydrochloride)

Meptazinol Hcl(WY-22811 Hcl) is a unique centrally active opioid analgesic.
in vitro: Meptazinol inhibits a portion of 3H-labeled opiate and opioid peptide binding quite potently, with IC50 value under 1 nM.
in vivo: Given at equianalgesic doses, morphine (3.5 mg/kg i.v.) significantly lowers the pO2 over 20 mm Hg and raises the pCO2 over 10 mm Hg as measured in arterial blood samples, whereas meptazinol (10 mg/kg i.v.) has no significant effects on either.  The group receiving meptazinol demonstrated no cardiovascular changes although bispectral index dropped by an additional 19% when compared to 1 min after barbiturate injection [2]. Rapid and significant levels of MEP in plasma and CSF can be achieved after nasal administration whereas the oral administration resulted in considerably lower drug concentrations.

For research only, not for human use!