LY-2409881(LY2409881)|IKK2 inhibitor|From DC Chemicals

LY-2409881(LY2409881)|IKK2 inhibitor|From DC Chemicals
LY2409881 is a novel inhibitor of IκB kinase β (IKK2).

Product name: LY2409881 trihydrochloride |Cat No. DC8065|Other names: LY-2409881,LY2409881|Cas: 946518-60-1|Molecule Weight: 594.43|Molecule Formular: C24H32Cl4N6OS| Purity: >98%

LY2409881 is a novel inhibitor of IκB kinase β (IKK2). LY2409881 inhibited constitutively activated NF-κB, and caused concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells. In models of diffuse large B-cell lymphoma (DLBCL), the cytotoxicity of LY2409881 correlated with the overall activation status of NF-κB, but not simply in a pattern predicted by the cell-of-origin classification of these cell lines. LY2409881 was safe to mice at three dose levels, 50, 100, and 200 mg/kg, all of which caused significant inhibition of tumor growth. LY2409881 suppressed the activity of the NF-κB subunit p65 in lymphoma cells treated by the HDAC inhibitor romidepsin, underlying a potential mechanism of the marked synergy observed of these two drugs.

For research and scientific purpose only, not for human use.