AZ5104(AZ-5104),metabolite of AZD9291|DC Chemicals
AG-120 is a first-in-class, orally available, selective, potent inhibitor of the mutated IDH1 protein.
Product name: AZ5104 |Cat No. DC8052|Other names: AZ5104,AZ-5104|Cas: 1421373-98-9|Molecule Weight: 485.58|Molecule Formular: C27H31N7O2| Purity: >98%
AZ5104 is an active circulating metabolite of AZD9291. It shares the similar overall activity profile with AZD9219, but is more potent against mutant EGFR forms, while hitting the wild-type EGFR form at a lower concentration thus demonstrating a smaller selectivity margin compared with the parent. Like AZD9291, AZ5104 displays potent antitumor activities both in vitro and in vivo, and is clinically competent with the parent.AZ5104 is a demethylated metabolite of AZD-9291. AZ-5104 was identified to exhibit 5-fold potency compared to AZD-9291, which is currently in clinical trial.
For research and scientific purpose only, not for human use.
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