AG-120(AG120)|IDH1 inhibitor| Supplied by DC Chemicals

AG-120(AG120)|IDH1 inhibitor| Supplied by DC Chemicals
AG-120 is a first-in-class, orally available, selective, potent inhibitor of the mutated IDH1 protein.

Product name: AG-120 |Cat No. DC8051|Other names: AG-120,AG120|Cas: 1448347-49-6|Molecule Weight: 582.969|Molecule Formular: C28H22ClF3N6O3| Purity: >98%

AG-120 is a first-in-class, orally available, selective, potent inhibitor of the mutated IDH1 protein, and is a highly targeted investigational medicine for the treatment of patients with cancers that harbor an IDH1 mutation. AG-120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells. IDH1, an enzyme in the citric acid cycle, is mutated in a variety of cancers; it initiates and drives cancer growth by both blocking cell differentiation and catalyzing the formation of 2HG.

For research and scientific purpose only, not for human use.