SC-514 supplier|SC514|DC Chemicals

SC-514 supplier|SC514|DC Chemicals
DC Chemicals provides SC-514, other names: SC514,SC 514, cas:  354812-17-2. In stock.

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A selective and reversible inhibitor of IKKβ

SC-514, other names: SC514,SC 514, cas:  354812-17-2, Molecule formular: C9H8N2OS2, Molecule Weight: 224.3, Chemical name: 5-(Thien-3-yl)-3-aminothiophene-2-carboxamide
4-Amino-[2,3'-bithiophene]-5-carboxamide

SC-514 is a selective and reversible inhibitor of IKKβ (IKK-2) (IC50 = 3-12 μM) that displays >10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. This compound attenuates NF-κB-induced gene expression of IL-6, IL-8 and Cox-2 (IC50 = 20, 20, and 8 μM, respectively). Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection. For the detailed information of SC-514, the solubility of SC-514 in water, the solubility of SC-514 in DMSO, the solubility of SC-514 in PBS buffer, the animal experiment (test) of  SC-514, the cell expriment (test) of SC-514, the in vivo, in vitro and clinical trial test of SC-514, the EC50, IC50,and affinity,of SC-514, Please contact DC Chemicals.