CX-5461 supplier|CX5461|DC Chemicals

CX-5461 supplier|CX5461|DC Chemicals
DC Chemicals provides CX-5461, other names: CX 5461,CX5461, cas: 1138549-36-6. In stock.

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CX-5461 is found to selectively inhibit rRNA synthesis (Pol I IC50=142 nM; Pol II IC50 > 25 μM; selectivity ~200-fold) in the HCT-116 cells.

CX-5461, other names: CX 5461,CX5461, cas: 1138549-36-6, Molecule formular: C27H27N7O2S, Molecule Weight: 513.61, Chemical name: 5H-Benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-

CX-5461 is found to selectively inhibit rRNA synthesis (Pol I IC50=142 nM; Pol II IC50 > 25 μM; selectivity ~200-fold) in the HCT-116 cells. Selective inhibition of rRNA synthesis by CX-5461 is confirmed in two other human solid tumor cell lines; melanoma A375 (Pol I IC50 = 113 nM; Pol II IC50 > 25 μM) and pancreatic carcinoma MIA PaCa-2 (Pol I IC50=54 nM; Pol II IC50 ~25 mM). CX-5461 possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation. CX-5461 exhibits broad antiproliferative potency in a panel of cancer cell lines in human cancer cell lines, but has minimal effect on viability of nontransformed human cells. The median EC50 across all tested cell lines is 147 nM, yet all normal cell lines have EC50 values of approximately 5, 000 nM. Evaluation of the antiproliferative dose response for HCT-116, A375, and MIA PaCa-2 cell lines yield EC50 values of 167, 58, and 74 nM. CX-5461 induces autophagy and senescence in solid tumor cancer cells, rather than apoptosis, through a p53-independent process. For the detailed information of CX-5461, the solubility of CX-5461 in water, the solubility of CX-5461 in DMSO, the solubility of CX-5461 in PBS buffer, the animal experiment (test) of  CX-5461, the cell expriment (test) of CX-5461, the in vivo, in vitro and clinical trial test of CX-5461, the EC50, IC50,and affinity,of CX-5461, Please contact DC Chemicals.