DC Chemicals supplies: (R)PFI 2 hydrochloride ,cas: N/A,Catalog: DC7679,In stock.
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Product name: (R)PFI 2 hydrochloride , Synonyms: PFI-2, PFI2,PFI 2, cas: N/A, MW: 536.98, Molecule Formula: C23H25F4N3O3S
PFI-2 (R-PFI-2), Purity:>98%. Best Price and high quality from DC Chemicals. PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd=18nM), and biotinylated PFI-2 interacts with SETD7 in pull-down studies.
PFI-2 is a potent and selective SETD7 histone lysine methyltransferase inhibitor (IC50 = 2 nM). Exhibits >1000-fold selectivity over DNMT1 and a panel of 18 other methyltransferases. Also inactive against a range of ion channels, GPCRs and enzymes. Inhibits YAP nuclear translocation and function following activation of the Hippo signaling pathway in MCF7 cells. PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd=18nM), and biotinylated PFI-2 interacts with SETD7 in pull-down studies.For the detailed information of PFI-2 (R-PFI-2), the solubility of PFI-2 (R-PFI-2) in water, the solubility of PFI-2 (R-PFI-2) in DMSO, the solubility of PFI-2 (R-PFI-2) in PBS buffer, the animal experiment (test) of PFI-2 (R-PFI-2), the cell expriment (test) of PFI-2 (R-PFI-2), the in vivo, in vitro and clinical trial test of PFI-2 (R-PFI-2), the EC50, IC50,and Affinity of PFI-2 (R-PFI-2), Please contact DC Chemicals.
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