DC Chemicals supplies: IM-12,cas: 1129669-05-1,Catalog: DC7680,In stock.
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Product name: IM-12, Synonyms: The GSK3β Inhibitor XIX, IM 12, IM-12,IM12 , cas: 1129669-05-1, MW: 377.41, Molecule Formula: C22H20FN3O2
IM-12, cas: 1129669-05-1, The GSK3β Inhibitor XIX, IM 12, IM-12,IM12 , Purity:>98%. Best Price and high quality from DC Chemicals. The GSK3β Inhibitor XIX, IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.
The GSK3β Inhibitor XIX, IM-12 controls the biological activity of GSK3β. This small molecule/inhibitor is primarily used For Phosphorylation & Dephosphorylation applications. It is a cell-permeable indolylmaleimide derivative and SB-216763 analog that acts as a GSK-3β inhibitor, with an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM For SB-216763 in the same assay condition, and reduces GSK-3β activity to 27% in an enzymatic assay at 3 ?M concentration. It is shown to attenuate hNPC (human neural progenitor cells) cell proliferation, and enrich β-catenin around the nucleus of ST14 cells in the same extent of SB-216763. Furthermore, it can mimic the effect of stabilized β-catenin, up-regulates TCF-activity in a luciferase reporter gene assay, and enhances human progenitor cell differentiation.For the detailed information of IM-12, the solubility of IM-12 in water, the solubility of IM-12 in DMSO, the solubility of IM-12 in PBS buffer, the animal experiment (test) of IM-12, the cell expriment (test) of IM-12, the in vivo, in vitro and clinical trial test of IM-12, the EC50, IC50,and Affinity of IM-12, Please contact DC Chemicals.
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