IWR-1|cas 1127442-87-8| DC Chem|Supplier|Price|Buy  

IWR-1|cas 1127442-87-8| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: IWR-1|cas 1127442-87-8,Purity: >98% ,Cat No. DC7053, In stock.

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IWR-1|cas 1127442-87-8 ,Synonym:  ,Chemical name: Benzamide,4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-,rel- ,Molecular Formula: C25H19N3O3 ,MW:409.44

IWR-1, cas 1127442-87-8,Purity: >98%, Best Price and quality from DC Chemicals. IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.

Although both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly.