CGK733|cas 905973-89-9| DC Chem|Supplier|Price|Buy
CGK733|cas 905973-89-9| DC Chem|Supplier|Price|Buy
DC Chemicals Supply: CGK733|cas 905973-89-9,Purity: >98% ,Cat No. DC7101, In stock.
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CGK733|cas 905973-89-9 ,Synonym: CGK-733; CGK 733 ,Chemical name: Benzeneacetamide,α-phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]- ,Molecular Formula: C23H18Cl3FN4O3S ,MW:555.84
CGK733, cas 905973-89-9,Purity: >98%, Best Price and quality from DC Chemicals. CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.
CGK733 is able to confer robust growth to senescent cells that have ceased proliferation. Senescence-associated β-galactosidase (SA–β-gal) activity disappears in CGK733-treated cells. CGK733 shows greater potency in inhibiting ATM/ATR than LY294002 (IC50 , ~5 μM for ATM and ATR), a pan-inhibitor of PI3K and PIKKs. [1] CGK733 (30 μM) treated for 24h causes ~60% cell death in senescent MCF-7 cells. [2] CGK733 (20 μM) induces the loss of cyclin D1 via the ubiquitin- dependent proteasomal degradation pathway in MCF-7 and T47D breast cancer cell lines. CGK733 at concentrations ranging from 0.6- 40 μM, inhibits proliferation of MCF-7 and T47D estrogen receptor (ER) positive breast cancer cells, MDA-MB436 ER negative breast cancer cells, LnCap pros-tate cancer cells and HCT116 colon cancer cells. Furthermore, CGK733 also suppresses proliferation of non- transformed mouse BALB/c 3T3 embryonic fibroblast cells. The CGK733-mediated inhibition of proliferation is dose dependent and significant at doses as low as 2.5 μM. [3]
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