CFTRinh 172|cas 307510-92-5| DC Chem|Supplier|Price|Buy  

CFTRinh 172|cas 307510-92-5| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: CFTRinh 172|cas 307510-92-5,Purity: >98% ,Cat No. DC7100, In stock.

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CFTRinh 172|cas 307510-92-5 ,Synonym:  ,Chemical name: Benzoicacid,4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]- ,Molecular Formula: C18H10F3NO3S2 ,MW:409.4

CFTRinh 172, cas 307510-92-5,Purity: >98%, Best Price and quality from DC Chemicals. Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and Escherichia coli and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen species (ROS) production independently of CFTR in several cell lines.

CFTRinh-172 dose- and time-dependently inhibits CFTR-mediated I- transportation, and effectively inhibits CFTR activation by multiple types of agonists or activators. [1] CFTRinh-172, as a selective CFTR channel inhibitor, also completely abolishes the Cl? current in the rabbit acinar and duct cells of rabbit lacrimal gland. [2]CFTRinh-172 also induces ROS production, mitochondrial failure, and activation of the NF-κB signaling pathway, independently of CFTR inhibition. [3] CFTRinh-172 (20 ?g/6 h) completely abolishes the V. cholerae-induced intestinal fluid secretion without affecting V. cholerae growth in vivo. [4]