BX795|cas 702675-74-9| DC Chem|Supplier|Price|Buy  

BX795|cas 702675-74-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: BX795|cas 702675-74-9,Purity: >98% ,Cat No. DC7092, In stock.

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BX795|cas 702675-74-9 ,Synonym: BX 795; BX-795  ,Chemical name: N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide ,Molecular Formula: C23H26IN7O2S ,MW:591.47

BX795, cas 702675-74-9,Purity: >98%, Best Price and quality from DC Chemicals. BX795 is a potent and selective dual inhibitor of TBK1/PDK1 with IC50s of 2 nM/6 nM respectively; > 50 fold selectivity over PKA, PKC, c-Kit, GSK3β etc.

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKK?, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [