BRL-15572 dihydrochloride|cas 1173022-77-9| DC Chem|Supplier|Price|Buy  

BRL-15572 dihydrochloride|cas 1173022-77-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: BRL-15572 dihydrochloride|cas 1173022-77-9,Purity: >98% ,Cat No. DC7091, In stock.

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BRL-15572 dihydrochloride|cas 1173022-77-9 ,Synonym: BRL-15572; BRL15572 ; BRL 15572 dihydrochloride; BRL15572 dihydrochloride  ,Chemical name: 3-(4-(3-chlorophenyl)piperazin-1-yl)-1,1-diphenylpropan-2-oldihydrochloride ,Molecular Formula: C25H27ClN2O.2HCl ,MW:479.87

BRL-15572 dihydrochloride, cas 1173022-77-9,Purity: >98%, Best Price and quality from DC Chemicals. BRL-15572 2Hcl is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor. 

BRL-15572 displays high affinity and selectivity for h5-HT1D receptors. BRL-15572 has 60-fold higher affinity for h5-HT1D than 5-HT1B receptors. BRL-15572 binds to h5-HT1B and h5-HT1D receptors with pKB of less than 6 and 7.1, respectively. BRL-15572 stimulates [35S]GTP γ S binding in both cell lines, with potencies that correlated with their receptor binding affinities in both h5-HT1B and h5-HT1D receptor expressing cell lines. BRL-15572 reveals receptor binding affinities for 5-HT1A, 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 with pKi of 7.7, 6.1, 5.2, 6.0, 6.6, 7.4, 6.2, 5.9 and 6.3, respectively. In the h5-HT1D cell line, both BRL-15572 (1 ?M) shifts the 5-HT concentration response curve with pKB of 7.1, respectively. BRL-15572 does have moderately high affinity at human 5-HT1A and 5-HT2B receptors. [1] In human atrial appendages, the electrically evoked tritium overflow is inhibited by 5-HT in a manner susceptible to antagonism by BRL-15572 (300 nM; 23 times Ki at h5-HT1D receptors). [2] The inhibitory effect of 5-HT on the K+-evoked overflow of glutamate is antagonized by the h5-HT1D receptor ligand BRL-15572. BRL-15572 (1 μM) is unable to modify the effect of 5-HT at the autoreceptor regulating [3H]5-HT release. [3] The selective 5-HT1D/1B receptor antagonist BRL 15572 inhibits the effect of the agonist L-694 247.