AZD8330(ARRY-424704; ARRY-704) |cas 1204531-17-8| DC Chem|Supplier|Price|Buy  

AZD8330(ARRY-424704; ARRY-704) |cas 1204531-17-8| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: AZD8330(ARRY-424704; ARRY-704) |cas 1204531-17-8,Purity: >98% ,Cat No. DC7077, In stock.

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AZD8330(ARRY-424704; ARRY-704) |cas 1204531-17-8 ,Synonym: ARRY-424704; ARRY-704; AZD-8330; ARRY424704; ARRY704; AZD8330  ,Chemical name: 2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide ,Molecular Formula: C16H17FIN3O4 ,MW:461.23

AZD8330(ARRY-424704; ARRY-704) , cas 1204531-17-8,Purity: >98%, Best Price and quality from DC Chemicals. AZD8330(ARRY-424704; ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM.

AZD8330 potently and strongly inhibits MEK 1/2. AZD8330 has no inhibitory activity against over 200 other kinases including at concentrations up to 10 μM. AZD8330 demonstrates sub-nanomolar potency in mechanistic (pERK) and low to sub-nanomolar potency in functional (proliferation) assays in MEK 1/2 inhibitor sensitive cell lines.  In a Calu-6 rat xenograft pharmacokinetic/pharmacodynamic (PK/PD) model a single, 1.25 mg/kg oral dose of AZD8330 inhibits ERK phosphorylation by > 90% for between 4 and 8 hours. Doses as low as 0.4 mg/kg once daily are sufficient for > 80% tumor growth inhibition in the Calu-6 nude rat xenograft model. In the Calu-6 model, AZD8330 inhibits tumor growth in a dose-dependent fashion, at 0.3 mg/kg and 1.0 mg/kg once daily.