AZD-8931|cas 848942-61-0| DC Chem|Supplier|Price|Buy

AZD-8931|cas 848942-61-0| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: AZD-8931|cas 848942-61-0,Purity: >98% ,Cat No. DC7078, In stock.

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AZD-8931|cas 848942-61-0 ,Synonym:  ,Chemical name: 2-(4-(4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-N-methylacetamide ,Molecular Formula: C23H25ClFN5O3 ,MW:473.93

AZD-8931, cas 848942-61-0,Purity: >98%, Best Price and quality from DC Chemicals. 

AZD8931 shows different potency to NSCLC and SCCHN cell lines. AZD8931 has high sensitivity to PC-9 cells (EGFR activating mutation) with GI50 of 0.1 nM and low activity to NCI-1437 cells with GI50 above 10 μM. AZD8931 exhibits more potency against phospho-EGFR, phospho-erbB2 and phospho-erbB3 than either lapatinib or gefitinib in PE/CA-PJ41, PE/CA-PJ49, DOK and FaDu cells. [1] AZD8931 reveals antitumor activity in BT474c, Calu-3, LoVo, FaDu and PC-9 xenografts. AZD8931 could reduce p-Akt, Ki67 expression and p-ERK in BT474c xenografts following acute treatment. AZD8931 also causes induction of the M30 apoptosis marker. Furthermore, AZD8931 shows greater proapoptotic effect compared with gefitinib and lapatinib in LoVo xenografts. [1]