ALW-II-41-27|cas 1186206-79-0
DC Chemicals, Website: www.dcchemicals.com
Product Name: ALW-II-41-27|Cas Number: 1186206-79-0| Catalog Number: DC10209|Other Nmaes: Eph receptor tyrosine kinase inhibitor
ALW-II-41-27 is a novel Eph receptor tyrosine kinase inhibitor, used for cancer treatment.
ALW-II-41-27 inhibits Ba/F3 cells transformed with Tel fusions of EphA3, Kit, Fms, KDR, FLT1, FGR, Src, Lyn, Bmx, and Bcr-Abl with an EC50 below 500 nM. ALW-II-41-27 exhibits cross reactivity with Bcr-Abl. ALW-II-41-27 inhibits b-raf, CSF1R, DDR1, DDR2, EphA2, EphA5, EphA8, EphB1, EphB2, EphB3, Frk, Kit, Lck, p38α, p38β, PDGFRα, PDGFRβ, and Raf1 and many more demonstrating how introduction of the thiophene group can have a tremendous impact on kinase selectivity[1].
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