SJ-172550|cas 431979-47-4|DC Chemicals

SJ-172550|cas 431979-47-4|DC Chemicals

SJ-172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.

IC50 value: 0.84 uM(EC50)

Target: MDMX inhibitor

in vitro: Unlike SJ-134433 and SJ-044557, SJ-172550 was stable in solution and did not modify the MDMX protein by covalent binding in our FP assay buffer.

Product Name: SJ-172550|Cat No: DC9506|Cas: 431979-47-4|Molecule Formular: C22H21ClN2O5|Molecule Weight: 428.8655|Other names: SJ-172550

SJ-172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
in vitro: Unlike SJ-134433 and SJ-044557, SJ-172550 was stable in solution and did not modify the MDMX protein by covalent binding in our FP assay buffer. MDMX-p53 interaction was at least partially inhibited by SJ-172550, despite its relatively low cell permeability. SJ-172550 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53.

For research only, not for human use!