SDZ 220-581 (hydrochloride)|cas 179411-93-9|DC Chemicals

SDZ 220-581 (hydrochloride)|cas 179411-93-9|DC Chemicals.

SDZ 220-581 Hcl is a potent, competitive antagonist at the NMDA glutamate receptor subtype(pKi= 7.7).

IC50 Value:

Target: NMDA receptor

in vitro: Wake-promoting doses of LSN2463359 and LSN2814617 attenuated deficits in performance induced by the competitiveNMDA receptor antagonist SDZ 220,581 in two tests of operant behaviour: the variable interval 30 s task and the DMTP task [1].

in vivo:  Administration of SDZ 220-581 or CGS 19755 was associated with a robust reduction in PPI, whereas L-701,324, 4-Cl-KYN or MLA failed to alter PPI [2].

Product Name: SDZ 220-581 (hydrochloride)|Cat No: DC9523|Cas: 179411-93-9|Molecule Formular: C16H18Cl2NO5P|Molecule Weight: 406.1976|Other names: SDZ 220-581 (hydrochloride)

SDZ 220-581 Hcl is a potent, competitive antagonist at the NMDA glutamate receptor subtype.
in vitro: Wake-promoting doses of LSN2463359 and LSN2814617 attenuated deficits in performance induced by the competitiveNMDA receptor antagonist SDZ 220,581 in two tests of operant behaviour: the variable interval 30 s task and the DMTP task.
in vivo:  Administration of SDZ 220-581 or CGS 19755 was associated with a robust reduction in PPI, whereas L-701,324, 4-Cl-KYN or MLA failed to alter PPI. With the most active agent, SDZ 220-581, full protection against maximal electroshock seizures (MES) was obtained at oral doses of 10 mg/kg in rats and in mice. The compound had a fast onset (< or = 1 hr) and a long duration (> or = 24 hr) of action. Rats were pretreated with clozapine (0 or 5.0 mg/kg) or haloperidol (0 or 0.1 mg/kg), together with SDZ 220-581 (0 or 2.5 mg/kg), and tested. SDZ 220-581 and SDZ EAB-515 decreased PPI without affecting startle magnitude.

For research only, not for human use!