MLN4924 (hydrochloride)|cas 1160295-21-5|DC Chemicals

MLN4924 (hydrochloride)|cas 1160295-21-5|DC Chemicals

MLN4924 Hcl is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50 = 4.7 nM).

IC50 value: 4.7 nM

Target: NAE

At much higher concentrations, MLN 4924 inhibits the related enzymes ubiquitin-activating enzyme (UAE) and SUMO-activating enzyme (SAE) with IC50 values of 1.5 and 8.2 μM, respectively.

Product Name: MLN4924 (hydrochloride)|Cat No: DC9518|Cas: 1160295-21-5|Molecule Formular: C21H26ClN5O4S|Molecule Weight: 479.9803|Other names: MLN4924 (hydrochloride)

MLN4924 Hcl is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50 = 4.7 nM).
At much higher concentrations, MLN 4924 inhibits the related enzymes ubiquitin-activating enzyme (UAE) and SUMO-activating enzyme (SAE) with IC50 values of 1.5 and 8.2 μM, respectively. At 0.3 μM, MLN 4924 has been shown to disrupt CRL-mediated protein turnover leading to apoptosis in HCT-116 cells by deregulating S-phase DNA synthesis. In vivo, 30-60 mg/kg MLN 4924 dose-dependently suppresses the growth of human tumor xenografts in mice.

For research only, not for human use!