MI 2 (MALT1 inhibitor)|cas 1047953-91-2|DC Chemicals

MI 2 (MALT1 inhibitor)|cas 1047953-91-2|DC Chemicals

MI 2(MALT1 inhibitor) is a small molecule and irreversible inhibitor of MALT1 with IC50 of 5.84 uM(suppression of proliferation in ABCDLBCL).

IC50 value: 5.84 uM

Target: MALT1

MI-2 selectively killed ABC-DLBCL cell lines with CD79A/B, CARMA1, and/or MYD88 mutations but not those occurring in proteins downstream of MALT1, including those with A20 homozygous deletion or TAK1 mutation.

Product Name: MI 2 (MALT1 inhibitor)|Cat No: DC9503|Cas: 1047953-91-2|Molecule Formular: C19H17Cl3N4O3|Molecule Weight: 455.7223|Other names: MI 2 (MALT1 inhibitor)

MI 2(MALT1 inhibitor) is a small molecule and irreversible inhibitor of MALT1 with IC50 of 5.84 uM(suppression of proliferation in ABCDLBCL).
MI-2 selectively killed ABC-DLBCL cell lines with CD79A/B, CARMA1, and/or MYD88 mutations but not those occurring in proteins downstream of MALT1, including those with A20 homozygous deletion or TAK1 mutation. Both MI-2 and Z-VRPR-FMK reduced nuclear c-REL to a similar extent, without affecting whole-cell levels of this protein. In both cell lines, exposure to MI-2 caused a clear reduction of nuclear c-REL whereas it did not affect p65 levels.

For research only, not for human use!