GW843682X is a cell-permeable thiophene-benzimidazole compound and reversible PLK inhibitor
Product Name: GW843682X |Catalog Number: DC8609 |CAS 660868-91-7 |Other names: Polo-like Kinase Inhibitor III |Chemical Name: |Molecule Formular: C22H18F3N3O4S |MW: 477.46
Polo-like Kinase Inhibitor III (GW843682X) is a cell-permeable thiophene-benzimidazole compound that acts as a potent and reversible inhibitor against Plk (polo-like kinases) (Ki against Plk1/2/3/4 = 4.8, 3.8, 8.0, and 163 nM , respectively), while exhibiting little or much reduced activity against 39 other commonly studied kinases. Polo-like Kinase Inhibitor III preferentially inhibits the proliferation of a panel of 11 tumor cell lines (IC50 ≤0.7 μM) over normal human diploid fibroblasts (IC50 = 6.14 μM) in culture and is equally potent against the mdr-1-expressing MES-SA/DX5 and its parent non-drug resistant MES-SA uterine sarcoma cell line.
For research only, not for human use.
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