WHI-P180(Janex 3)|EGFR/CDK2 inhibitor|DC Chemicals

WHI-P180(Janex 3)|EGFR/CDK2 inhibitor|DC Chemicals
WHI-P180(Janex 3) is a potent inhibitor of IgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (CDK2; IC50 = 1µM) by blocking the ATP site

Product name: WHI-P180(Janex 3) |Cat No. DC8068|Other names: WHI-P180,Janex 3|Cas: 211555-08-7|Molecule Weight: 297.31|Molecule Formular: C16H15N3O3| Purity: >98%

WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
in vitro: WHI-P180 moderately inhibited ABCG2 function, exhibiting weak phototoxicity.
in vivo: The elimination half-life of WHI-P180 in CD-1 mice (BALB/ c mice) following i.v., i.p., or p.o. administration was less than 10 min. Systemic clearance of WHI-P180 was 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibited IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.

For research and scientific purpose only, not for human use.