SNG-1153(SNG1153)|ER-α36 modulator|DC Chemicals

SNG-1153(SNG1153)|ER-α36 modulator|DC Chemicals
SNG-1153 is a synthetic modulator of ER-α36

Product name: SNG-1153 |Cat No. DC8049|Other names: |Cas: N/A|Molecule Weight: 406.1|Molecule Formular: C21H17F305| Purity: >98%

SNG1153 is a synthetic ER-α36 modulator, showed promising activities in many in vitro and in vivo models. In-vivo efficacies of SNG1153 were evaluated in Bcap-37 xenograft model, Ishikawa xenograft model and SPC-A-1 xenograft model. Results: SNG1153 showed significant inhibition at low micromolar concentrations in ER-α36 overexpressed cell lines including the one resistant to tamoxifen. SNG1153 exhibited a linear PK profile with a bioavailability of more than 55% in the rat PK study. In the in-vivo efficacy studies, 3 doses were investigated and SNG1153 showed dose-dependent inhibition. The tumor growth inhibition at high dose was 57% in the breast cancer Bcap-37 xenograft model, 65% in the endometrial cancer Ishikawa xenograft model and 52% in lung adenocarcinoma SPC-A-1 xenograft model. No signs of toxicity were observed in these model.

For research and scientific purpose only, not for human use.