Pyridoclax(MR29072)|MR-29072,MR 29072|DC Chemicals

Pyridoclax(MR29072)|MR-29072,MR 29072|DC Chemicals
Pyridoclax(MR-29072) is a potent Mcl-1 inhibitor with Kd value of 25 nM.

Catlog: DC8128| Product name: Pyridoclax(MR29072)| Cas: 1651890-44-6| Other names: MR-29072,MR 29072| Molecule Formula: C29H22N4| MW: 426.51. Purity: >98%

Price: 100mg: 700 USD; 250mg: 1300 USD; 1000mg: 2600 USD

Pyridoclax is able to disrupt BimL/Mcl-1 interaction in whole living cells. Pyridoclax strongly sensitizes ovarian cancer chemoresistant IGROV1-R10 cells to Bcl-xL targeting siRNA, their combination leading to massive apoptosis. Neither ABT-737 nor Pyridoclax induced cell death as single agents, whereas their combination led to massive apoptotic cell death in both IGROV1-R10 and SKOV3 chemoresistant ovarian cancer cell lines.

For research and scientific purpose only, not for human use.