PLX3397 (Pexidartinib)|CSF1 inhibitor|DC Chemicals

PLX3397 (Pexidartinib)|CSF1 inhibitor|DC Chemicals
PLX3397 is a tyrosine kinase inhibitor that potently inhibits the colony stimulating factor 1 (CSF1) receptor kinase, a driving force in the development and growth of PVNS.

Catlog: DC8158| Product name: Pexidartinib(PLX3397)| Cas: 1029044-16-3| Other names: PLX3397,PLX 3397,PLX-3397| Molecule Formula: C20H15ClF3N5| MW: 417.81. Purity: >98%

Price: 100mg: 700 USD; 250mg: 1200 USD; 1000mg: 2200 USD

In the study, 23 patients with advanced PVNS in a single joint received 1000 mg of PLX3397 orally each day. Patients underwent an MRI every two months to measure tumor volume using a novel tumor volume score developed for PVNS. Among the 14 patients with evaluable MRI scans, the mean tumor size reduction was 61 percent. Eleven patients experienced a partial response (at least a 50 percent decrease in tumor volume compared to baseline screenings) and three had stable disease. Patients remained on the drug until disease progression or intolerability.

The most common treatment-related side effects were hair-color changes, f

For research and scientific purpose only, not for human use.