ALLM (Calpain Inhibitor)|Ac-LLM-CHO|DC Chemicals

ALLM (Calpain Inhibitor)|Ac-LLM-CHO|DC Chemicals
ALLM (Calpain Inhibitor) is cell-permeable, peptide aldehyde inhibitor of calpains and cathepsins.

Product name: ALLM (Calpain Inhibitor) |Cat No. DC8106|Other names: ALLM (Calpain Inhibitor) |Cas: 136632-32-1|Molecule Weight: 401.56|Molecule Formular: C19H35N3O4S1| Purity: >95%

ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki = 120 nM) and calpain II (Ki = 230 nM). ALLM acts as a very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.

For research and scientific purpose only, not for human use.