NVP-BEP800 supplier|VER82576|DC Chemicals

NVP-BEP800 supplier|VER82576|DC Chemicals
DC Chemicals provides NVP-BEP800, other names: VER82576, cas: 847559-80-2. In stock.

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NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM, exhibits>70-fold selectivity against Hsp90 family members Grp94 and Trap-1.

NVP-BEP800, other names: VER82576, cas: 847559-80-2, Molecule formular: C21H23Cl2N5O2S, Molecule Weight: 480.41, Chemical name: 2-amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide

NVP-BEP800 is an ATP-competitive inhibitor of Hsp90β with an IC50 of 58 nM, exhibiting >70-fold selectivity against Hsp90 family members Grp94 and Trap-1 with IC50 values of 4.1 μM and 5.5 μM, respectively. NVP-BEP800 displays no inhibitory activity against the closely related GHKL ATPase, topoisomerase II, and the structurally unrelated ATPase, Hsp70 at the concentration of 10 μM. NVP-BEP800 potently inhibits the proliferation of various tumor cell lines with GI50 values ranging from 38 nM in A375 to 1.05 μM in PC3, and primary human tumors with the mean IC50 of 0.75 μM and IC70 of 1.8 μM. NVP-BEP800 treatment at the concentration of five times the GI50 increases the percentage of G2-M phase in A2058 and A549 cells and sub-G1 phase in BT-474, HCT116, A2058 and A549 cells by 29.5%, 33.6%, 42.7%, 12.1%, 5.9% and 7.1%, respectively. NVP-BEP800 treatment causes Akt and ErbB2 dephosphorylation, ErbB2 degradation, and Hsp70 induction in a concentration-dependent manner in BT-474 cells with IC50 values of 218 nM, 39.5 nM, 137 nM and 207 nM, respectively. For the detailed information of NVP-BEP800, the solubility of NVP-BEP800 in water, the solubility of NVP-BEP800 in DMSO, the solubility of NVP-BEP800 in PBS buffer, the animal experiment (test) of  NVP-BEP800, the cell expriment (test) of NVP-BEP800, the in vivo, in vitro and clinical trial test of NVP-BEP800, the EC50, IC50,and affinity,of NVP-BEP800, Please contact DC Chemicals.