Epoxomicin supplier|BU-4061T|DC Chemicals

Epoxomicin supplier|BU-4061T|DC Chemicals
DC Chemicals provides Epoxomicin, other names: Epoxomicin,BU4061T,BU-4061T, cas: 134381-21-8. In stock.

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Epoxomicin is a selective and irreversible inhibitor of 20S proteasome with an IC50 value of 4 nM.

Epoxomicin, other names: Epoxomicin,BU4061T,BU-4061T, cas: 134381-21-8, Molecule formular: C28H50N4O7, Molecule Weight: 554.7, Chemical name: (2S,3S)-2-[[(2S,3S)-2-[acetyl(methyl)amino]-3-methylpentanoyl]amino]-N-[(2S,3R)-3-hydroxy-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]-3-methylpentanamide

Epoxomicin is a potent proteasome inhibitor, primarily inhibiting the activity of CTRL(chymotrypsin-like proteasome). The novel α-epoxy ketone moiety of Epoxomicin forms covalent bonds with residues in particular catalytic subunits of the enzyme, disabling activity. The trypsin-like and peptidyl-glutamyl peptide hydrolyzing behavior of the proteasome were both inhibited by Epoxomicin as well (at 100 and 1,000-fold slower rates, respectively). Bone formation is heavily regulated by the ubiquitin-proteasome pathway, and Epoxomicin was shown to increase both bone volume and bone formation rates in rodents. Another study demonstrates that exposure to Epoxomicin and other proteasome inhibitors leads to dopaminergic cell death, producing a model of Parkinson's disease in vivo. Epoxomicin is an inhibitor of 20S Proteasome. For the detailed information of Epoxomicin, the solubility of Epoxomicin in water, the solubility of Epoxomicin in DMSO, the solubility of Epoxomicin in PBS buffer, the animal experiment (test) of  Epoxomicin, the cell expriment (test) of Epoxomicin, the in vivo, in vitro and clinical trial test of Epoxomicin, the EC50, IC50,and affinity,of Epoxomicin, Please contact DC Chemicals.