MMAF|745017-94-1|buy from supplier D&C Chemicals

MMAF|745017-94-1|buy from supplier D&C Chemicals

DC Chemicals supplies: MMAF,cas: 745017-94-1,Catalog: DC7685,In stock.

Contact: website: www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-58447131;Fax:+86-21-61643258；

Product name: MMAF, Synonyms: monomethylauristatin F, MMAF; Monomethyl auristatin phenylalanine; 745017-94-1, cas: 745017-94-1, MW:  731.9621 , Molecule Formula: C39H65N5O8 

MMAF, purity: >98%, Best price from D&C Chemicals. Monomethylauristatin F(MMAF) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody drug cytotoxin.

Monomethylauristatin F(MMAF) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody drug cytotoxin.

IC50 value:

Target: tubulin; ADCs cytotoxin

MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself.  MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.

For the detailed information about the solubility of MMAF in water, the solubility of MMAF in DMSO, the solubility of MMAF in PBS buffer, the animal experiment of MMAF,the in vivo and in vitro test of MMAF,the cell experiment of MMAF,the IC50 and EC50 of MMAF please contact DC Chemicals.