BX-471|cas217645-70-0|Price|Buy|Supplied by DC Chemicals

BX-471|cas217645-70-0|Price|Buy|Supplied by DC Chemicals

DC Chemicals supplies: BX-471,cas: 217645-70-0,Catalog: DC7675,In stock.

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Product name: BX-471, Synonyms: (BX-471; BX 471), cas: 217645-70-0, MW: 434.89, Molecule Formula: C21H24ClFN4O3

BX-471, cas: 217645-70-0, (BX-471; BX 471), Purity:>98%. Best  Price and high quality from DC Chemicals. BX471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1); exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.

BX471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM  For human CCR1); exhibits 250-fold selectivity  For CCR1 over CCR2, CCR5 and CXCR4.

IC50 value: 1 nM(Ki) 

Target: CCR1

BX471 inhibits MIP-α/CCL3-induced intracellular Ca2+ mobilization. BX471 is orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy.

Exhibits 250-fold selectivity  For CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP-α/CCL3-induced intracellular Ca2+ mobilization. Orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy.For the detailed information of BX-471, the solubility of BX-471 in water, the solubility of BX-471 in DMSO, the solubility of BX-471 in PBS buffer, the animal experiment (test) of  BX-471, the cell expriment (test) of BX-471, the in vivo, in vitro and clinical trial test of BX-471, the EC50, IC50,and Affinity of BX-471, Please contact DC Chemicals.