R306465(JNJ-16241199)|cas 604769-01-9| DC Chem|Supplier|Price|Buy  

R306465(JNJ-16241199)|cas 604769-01-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: R306465(JNJ-16241199)|cas 604769-01-9,Purity: >98% ,Cat No. DC7037, In stock.

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R306465(JNJ-16241199)|cas 604769-01-9 ,Synonym:  ,Chemical name: N-hydroxy-2-(4-(naphthalen-2-ylsulfonyl)piperazin-1-yl)pyrimidine-5-carboxamide ,Molecular Formula: C19H19N5O4S ,MW:413.11

R306465(JNJ-16241199), cas 604769-01-9,Purity: >98%, Best Price and quality from DC Chemicals. R306465, also known as JNJ-16241199, is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models.

R306465, also known as JNJ-16241199, is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models.R306465 was found to be a potent inhibitor of HDAC1 and -8 (class I) in vitro.  R306465 potently inhibited cell proliferation of all main solid tumour indications, including ovarian, lung, colon, breast and prostate cancer cell lines, with IC50 values ranging from 30 to 300 nM.  The high activity of R306465 in cell-based assays and in vivo after oral administration makes R306465 a promising novel antitumoral agent with potential applicability in a broad spectrum of human malignancies. (source: British journal of cancer (2007), 97(10), 1344-53.)