Otenabant (CP-945598)|cas 686344-29-6| DC Chem|Supplier|Price|Buy

Otenabant (CP-945598)|cas 686344-29-6| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Otenabant (CP-945598)|cas 686344-29-6,Purity: >98% ,Cat No. DC7109, In stock.

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Otenabant (CP-945598)|cas 686344-29-6 ,Synonym: CP 945598; CP-945598; CP945598  ,Chemical name: 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]-4-(ethylamino)piperidine-4-carboxamide ,Molecular Formula: C25H25Cl2N7O  ,MW: 510.4183 

Otenabant (CP-945598), cas 686344-29-6,Purity: >98%, Best Price and quality from DC Chemicals. Otenabant (CP945598) is a recently discovered selective, high affinity, competitive CB1 receptor antagonist with Ki of 0.7 nM. 

CP-945598 HCl inhibits CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate CNS penetration. [1] CP-945598 HCl has low affinity with Ki of 7.6 μM for human CB2 receptors. [2] CP-945598 HCl reverses four cannabinoid agonistmediated behaviors (locomotor activity, hypothermia, analgesia, and catalepsy) following administration of the synthetic CB1 receptor agonist CP-55940. CP-945598 HCl exhibits dose-dependent anorectic activity in a model of acute food intake in rodents and increased energy expenditure and fat oxidation. [1] CP-945598 also acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation. CP-945598 at 10 mg/kg promotes a 9%, vehicle adjusted weight loss in a 10 day weight loss study in diet-induced obese mice. [2]