KPT-330|cas 1393477-72-9| DC Chem|Supplier|Price|Buy  

KPT-330|cas 1393477-72-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: KPT-330|cas 1393477-72-9,Purity: >98% ,Cat No. DC7067, In stock.

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KPT-330|cas 1393477-72-9 ,Synonym: KPT330; KPT 330  ,Chemical name: (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide ,Molecular Formula: C17H11F6N7O ,MW:443.31

KPT-330, cas 1393477-72-9,Purity: >98%, Best Price and quality from DC Chemicals. KPT-330, analog of KPT-185, is an orally bioavailable selective CRM1 inhibitor.

As the clinical candidate analog of KPT-185, KPT-330 exhibits similar effects on the viability of T-ALL cells and elicits rapid apoptotic response. KPT-330 also reduces cell growth in MOLT-4, Jurkat, HBP-ALL, KOPTK-1, SKW-3, and DND-41 cell lines, with IC50 values of 34-203 nM. [1] KPT-330 dramatically suppresses the growth of T-ALL cells (MOLT-4) and AML cells (MV4–11) in vivo, with little toxicity to normal haematopoietic cells. [1] In SCID mice with diffuse human MM bone lesions, KPT-330 inhibits MM-induced bone lysis and prolongs survival. Moreover, KPT-330 directly impairs osteoclastogenesis and bone resorption by blocking RANKL-induced NF-κB and NFATc1, with minimal impact on osteoblasts and BMSCs. [2]