FK866(APO866; K 22.175) |cas 658084-64-1| DC Chem|Supplier|Price|Buy

FK866(APO866; K 22.175) |cas 658084-64-1| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: FK866(APO866; K 22.175) |cas 658084-64-1,Purity: >98% ,Cat No. DC7062, In stock.

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FK866(APO866; K 22.175) |cas 658084-64-1 ,Synonym: K 22.175; APO866; FK-866; FK 866; APO 866; APO-866  ,Chemical name: (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide ,Molecular Formula: C24H29N3O2 ,MW:391.51

FK866(APO866; K 22.175) , cas 658084-64-1,Purity: >98%, Best Price and quality from DC Chemicals. FK866(APO866; K 22.175) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM. 

APO866 at low concentrations ranging from 0.09-27 nM induces dose-dependent cytotoxicity in 41 hematologic malignant cells including acute myeloid leukemia [AML], acute lymphoblastic leukemia [ALL], mantle cell lymphoma [MCL], chronic lymphocytic leukemia [CLL], and T-cell lymphoma. APO866 at low concentrations ranging from 0-10 nM induces cell death, this effect is independent of caspase activation but is associated with depolarization of mitochondrial membrane. APO866 at concentrations ranging from 0-10 nM dose-dependently induces depletion of intracellular NAD and ATP contents and cell death in various hematologic cancer cells. [1]APO866 at concentration of 10 nM inhibits PBEF-induced secretion of MMP-3, CCL2, and CXCL8 in HFFF2 cells. [2] APO866 administered intraperitoneally at dose of 20 mg/kg twice a day for 4 days, repeat weekly over 3 weeks, prevents and abrogats tumor growth in C.B.-17 SCID mice xenograft models of human AML, lymphoblastic lymphoma, and leukemia. [1] APO866 at dose of 0.12 mg/kg/hour prevents joint destruction and leukocyte infiltration through inhibition of PBEF in mice with CIA. [2]