CFTR Inhibitor II|cas 328541-79-3| DC Chem|Supplier|Price|Buy  

CFTR Inhibitor II|cas 328541-79-3| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: CFTR Inhibitor II|cas 328541-79-3,Purity: >98% ,Cat No. DC7039, In stock.

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CFTR Inhibitor II|cas 328541-79-3 ,Synonym:  ,Chemical name: N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycinehydrazide ,Molecular Formula: C19H15Br2N3O3 ,MW:493.2

CFTR Inhibitor II, cas 328541-79-3,Purity: >98%, Best Price and quality from DC Chemicals. CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 ?M; Ki = 4.3 ?M in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. 

A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 ?M; Ki = 4.3 ?M in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo. Also available as a 25 mM solution in DMSO