BYL-719|cas 1217486-61-7| DC Chem|Supplier|Price|Buy 

BYL-719|cas 1217486-61-7| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: BYL-719|cas 1217486-61-7,Purity: >98% ,Cat No. DC7094, In stock.

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BYL-719|cas 1217486-61-7 ,Synonym: BYL 719; BYL719  ,Chemical name: 1,2-Pyrrolidinedicarboxamide,N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-,(2S)- ,Molecular Formula: C19H22F3N5O2S ,MW:441.47

BYL-719, cas 1217486-61-7,Purity: >98%, Best Price and quality from DC Chemicals. BYL719 is a potent and selective PI3Kα inhibitor with IC50 of 5 nM, ;liitle or no effect on PI3Kβ/γ/δ.

BYL719 inhibits the proliferation of breast cancer cell lines harboring PIK3CA mutations, correlating with inhibition of various downstream signaling components of the PI3K/Akt pathway. BYL719(>270 mg/d) shows statistically significant dose-dependent anti-tumor efficacy in PIK3CA mutant xenograft models in rodents. BYL719 has a low clearance, a half-life of 8.5 h and its exposure increases dose proportionally between 30mg/d and 450mg/d, displaying a low inter-individual variability in Cmax and AUC in human. BYL719(270mg/d) shows first signs of clinical efficacy include 1 confirmed partial response in a patient with ER+ breast cancer, and significant PET responses (PMR) and/or tumor shrinkage are achieved in 8 out of 17 evaluated patients.