BIBR-1532|cas 321674-73-1| DC Chem|Supplier|Price|Buy  

BIBR-1532|cas 321674-73-1| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: BIBR-1532|cas 321674-73-1,Purity: >98% ,Cat No. DC7085, In stock.

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BIBR-1532|cas 321674-73-1 ,Synonym: BIBR1532; BIBR-1532  ,Chemical name: (E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoicacid ,Molecular Formula: C21H17NO3 ,MW:331.36

BIBR-1532, cas 321674-73-1,Purity: >98%, Best Price and quality from DC Chemicals. BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM.

BIBR 1532 exhibits an non-competitive inhibitory effect on telomerase activity. [1] In JVM13 leukemia cell line, BIBR 1532 shows an antiproliferative effect in a dose-dependent range with IC50 of 52 μM, and similar results are also observed in other leukemia cell lines including Nalm-1, HL-60, and Jurkat. In addition, BIBR 1532 results in a direct antiproliferative effect on acute myeloid leukemia (AML) with IC50 of 56 μM without affecting the proliferative capacity of normal hematopoietic progenitor cells. [2] BIBR 1532 (2.5 μM) reduces colony-forming ability, and induces telomere length shortening as well as chemotherapeutic sensitization by inhibiting telomerase activity in MCF-7/WT and melphalan-resistant MCF-7/MlnR cell lines. [3] In T-cell prolymphocytic leukemia (T-PLL), BIBR 1532 shows selective cytotoxic effects in a dose-dependent manner and BIBR 1532-treated cells also demonstrates nuclear condensation and formation of apoptotic bodies morphologically compatible with apoptosis. [4] A recent study shows that combination treatment of BIBR 1532 and chemotherapeutic agents carboplatin results in a potential synergy for eliminateing ovarian cancer spheroid-forming cells in ES2, SKOV3, and TOV112D cell lines. [5]