BI-D1870|cas 501437-28-1| DC Chem|Supplier|Price|Buy  

BI-D1870|cas 501437-28-1| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: BI-D1870|cas 501437-28-1,Purity: >98% ,Cat No. DC7098, In stock.

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BI-D1870|cas 501437-28-1 ,Synonym:  ,Chemical name: 2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone ,Molecular Formula: C??H??F?N?O? ,MW:391.42

BI-D1870, cas 501437-28-1,Purity: >98%, Best Price and quality from DC Chemicals. BI-D1870 is a small molecule, specific inhibitor of p90 RSK (ribosomal S6 kinase) isoforms RSK1, RSK2, RSK3 and RSK4, both in vitro and in vivo, with IC50s are 31 nM, 24 nM, 18 nM, 15 nM, respectively. It shows a 10- to 100-fold 

Cell-permeable. ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC??'s at 100 ?M ATP: RSK1 = 31 nM, RSK2 = 24 nM, RSK3 = 18 nM, RSK4 = 15 nM). Does not significantly inhibit 10 other AGC kinases, and over 40 other protein kinases at 100X concentrations.  In addition, BI-D1870 completely prevents PMA-induced TSC2 (a regulator of mTORC1) phosphorylation at Ser????.