AZD2014|cas 1009298-59-2| DC Chem|Supplier|Price|Buy  

AZD2014|cas 1009298-59-2| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: AZD2014|cas 1009298-59-2,Purity: >98% ,Cat No. DC7073, In stock.

Contact: website:www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-61454686;Fax:+86-21-61642542；

AZD2014|cas 1009298-59-2 ,Synonym: AZD 2014; AZD-2014  ,Chemical name: 3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide ,Molecular Formula: C25H30N6O3 ,MW:462.54

AZD2014, cas 1009298-59-2,Purity: >98%, Best Price and quality from DC Chemicals. AZD2014 is a novel mTOR inhibitor with IC50 of 2.8 nM; highly selective against multiple PI3K isoforms (α/β/γ/δ). 

AZD2014 is a close analogue of AZD8055 and a selective inhibitor of mTOR kinase. AZD2014 has greater inhibitory activity against mTORC1 compared to rapamycin: AZD2014 decreases p4EBP1 Thr37/46, inhibits the translation initiation complex and decreases overall protein synthesis while rapamycin has no effect. AZD2014 also inhibits the mTORC2 biomarkers pAKTSer473 and pNDRG1Thr346. AZD2014 has broad antiproliferative activity across multiple tumour cell lines. In particular, AZD2014 induces growth inhibition and cell death in breast cancer cell lines, including ER+ cell lines with acquired resistance to hormone therapy. AZD2014 induces tumour growth inhibition against several xenograft models including a human primary explant model of ER+ breast cancer refractory to tamoxifen. The antitumour activity is associated with modulation of both mTORC1 and mTORC2 substrates.