AZD1152 (barasertib)|cas 722543-31-9| DC Chem|Supplier|Price|Buy DC Chemicals Supply: AZD1152 (barasertib)|cas 722543-31-9,Purity: >98% ,Cat No. DC7060, In stock. Contact: website: www.dcchemicals.com, sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com, Tel: +86-21-61454686;Fax:+86-21-61642529； AZD1152 (barasertib)|cas 722543-31-9 ,Synonym: Barasertib; AZD-1152; AZD 1152 ,Chemical name: 2-[ethyl-[3-[4-[[5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl]amino]quinazolin-7-yl]oxypropyl]amino]ethyldihydrogenphosphate ,Molecular Formula: C26H31FN7O6P ,MW:587.539805 AZD1152 (barasertib), cas 722543-31-9,Purity: >98%, Best Price and quality from DC Chemicals. AZD1152 (barasertib), pro-drug of barasertib-hQPA(HY-10126), is a selective Aurora B kinase inhibitor, AZD1152 inhibited the proliferation various types of human leukemia cells with an IC50 ranging from 3 nM to 40 nM. An orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase inhibitor AZD1152–hydroxyquinazoline pyrazol anilide (AZD1152-HQPA) with potential antineoplastic activity. Upon administration and rapid conversion from the prodrug form in plasma, barasertib specifically binds to and inhibits Aurora kinase B, which results in the disruption of spindle checkpoint functions and chromosome alignment and, so, the disruption of chromosome segregation and cytokinesis. Consequently, cell division and cell proliferation are inhibited and apoptosis is induced in Aurora kinase B-overexpressing tumor cells. Aurora kinase B, a serine/threonine protein kinase that functions in the attachment of the mitotic spindle to the centromere, is overexpressed in a wide variety of cancer cell types.

AZD1152 (barasertib)|cas 722543-31-9| DC Chem|Supplier|Price|Buy  

AZD1152 (barasertib)|cas 722543-31-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: AZD1152 (barasertib)|cas 722543-31-9,Purity: >98% ,Cat No. DC7060, In stock.

Contact: website: www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-61454686;Fax:+86-21-61642529；

AZD1152 (barasertib)|cas 722543-31-9 ,Synonym: Barasertib; AZD-1152; AZD 1152 ,Chemical name: 2-[ethyl-[3-[4-[[5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl]amino]quinazolin-7-yl]oxypropyl]amino]ethyldihydrogenphosphate ,Molecular Formula: C26H31FN7O6P  ,MW:587.539805

AZD1152 (barasertib), cas 722543-31-9,Purity: >98%, Best Price and quality from DC Chemicals. AZD1152 (barasertib), pro-drug of barasertib-hQPA(HY-10126), is a selective Aurora B kinase inhibitor, AZD1152 inhibited the proliferation various types of human leukemia cells with an IC50 ranging from 3 nM to 40 nM.

An orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase inhibitor AZD1152–hydroxyquinazoline pyrazol anilide (AZD1152-HQPA) with potential antineoplastic activity. Upon administration and rapid conversion from the prodrug form in plasma, barasertib specifically binds to and inhibits Aurora kinase B, which results in the disruption of spindle checkpoint functions and chromosome alignment and, so, the disruption of chromosome segregation and cytokinesis. Consequently, cell division and cell proliferation are inhibited and apoptosis is induced in Aurora kinase B-overexpressing tumor cells. Aurora kinase B, a serine/threonine protein kinase that functions in the attachment of the mitotic spindle to the centromere, is overexpressed in a wide variety of cancer cell types.