AT9283|cas 896466-04-9| DC Chem|Supplier|Price|Buy  

AT9283|cas 896466-04-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: AT9283|cas 896466-04-9,Purity: >98% ,Cat No. DC7070, In stock.

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AT9283|cas 896466-04-9 ,Synonym: AT-9283; AT 9283  ,Chemical name: 1-cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea ,Molecular Formula: C19H23N7O2 ,MW:381.43

AT9283, cas 896466-04-9,Purity: >98%, Best Price and quality from DC Chemicals. AT9283 is a small molecule a multi-targeted inhibitor with of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl(T3151), Jak2 and Jak3, aurora A and B, respectively.

AT9283 leads to a clear polyploid phenotype by inhibiting the activity of Aurora B kinase in HCT116 cells with IC50 of 30 nM. Furthermore, AT9283 also produces the potent inhibition on HCT116 colony formation. [1] In HCT116 human colon carcinoma xenograft bearing mice, AT9283 treatment (15 mg/kg and 20 mg/kg) for 16 days results in a significant tumor growth inhibition of 67% and 76%, respectively. In addition, AT9283 also exhibits a significantly longer half-life in tumors(2.5 hours) compared with plasma (0.5 hour) and modest oral bioavailability in mice (Fp.o. = 24%). [1]