AG-18|cas 118409-57-7| DC Chem|Supplier|Price|Buy  

AG-18|cas 118409-57-7| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: AG-18|cas 118409-57-7,Purity: >98% ,Cat No. DC7051, In stock.

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AG-18|cas 118409-57-7 ,Synonym: RG-50810; Tyrphostin A23; AG-18; AG18; RG 50810; RG50810  ,Chemical name: Propanedinitrile,2-[(3,4-dihydroxyphenyl)methylene]- ,Molecular Formula: C10H6N2O2 ,MW:186.17

AG-18, cas 118409-57-7,Purity: >98%, Best Price and quality from DC Chemicals. AG-18(RG-50810; Tyrphostin A23) inhibits EGFR with IC50 of 40 μM.

AG 18 inhibits EGFR and IR with Ki of 11 μM and 12 mM. AG 18 inhibits EGF-induced EGFR autophoshporylation with IC50 of 15 μM in A431 cells. [1] AG 18 (10 μM) inhibits EGF-induced proliferation of GH3 cells. AG 18 (10 μM) causes significant inhibition of the cell proliferation induced by 10 nM and 1 μM ghrelin. AG 18 (10 μM) blocks the ghrelin-stimulated increase in ERK 1/2 phosphorylation in GH3 cells. [2]AG 18 inhibits the volume-sensitive release of [3H]taurine in primary astrocyte cultures in a dose-dependent manner. AG 18 activates swelling-induced volume-dependent D-[3H]aspartate release from primary astrocytic cultures. [3] AG 18 (300 μM) inhibits TPA-induced stimulation of ICAM-1 expression in a dose dependent manner in A549 epithelial cells. AG 18 (300 μM) also inhibits TPA stimulated NF-kappaB DNA-protein binding and ICAM-1 promoter activity in A549 epithelial cells. AG 18 (300 μM) inhibits TNF-alpha-induced NF-kappaB DNA-protein binding and ICAM-1 promoter activity in a dose dependent manner in A549 epithelial cells. IKK activity is stimulated by both TNF-alpha and TPA, and these effects are inhibited by AG 18 (100 μM) in A549 epithelial cells. [4] AG 18 (10 μM) decreases the potency of 5-HT 4-fold and reduces the maximal contraction to 5-HT in the carotid artery. AG 18 (10 μM) shifts KCl-induced contraction 2-fold and causes the maximum significantly inhibition.